Barcelona have confirmed Griezmann has suffered a muscle injury and will miss the remainder of their La Liga campaign.
The 29 year old forward started for Quique Setien’s team as they beat Real Valladolid 1-0 on Saturday.
He was later replaced at half time, with Luis Suarez coming on to partner Lionel Messi up front.
Setien confirmed after the game that Griezmann was asked to come off because he was feeling some discomfort.
Griezmann had to undergo scans on his right leg on Sunday which revealed he had suffered an injury.
It is however unknown when the player will return as the season according to Barcelona.
Read Club’s Statements:
“Tests this morning have shown that first-team player Antoine Griezmann has a muscle injury in the quadriceps of his right leg.
“He is therefore not available for selection at the present time and the evolution of the injury will condition his availability.”
Griezmann will be unavailable for Thursday’s match against Osasuna and likely miss the final clash with Deportivo Alaves on July 19.
Since joining the Camp Nou outfit from Atletico Madrid last summer, has scored nine goals in 35 appearances.
The attacker’s injury will likely see Suarez return to the starting XI for the last two matches.
Setien confirmed on Saturday that he was just being rested after playing five games in a row.
The Catalan side are second on the league top flight and trail leaders Real Madrid by one point.
Barca will then turn their attention to their Champions League on August 8 when they face Napoli in the second leg of their last-16 tie.
The two sides played 1-1 in the first match in Italy in Febraury before football break.