He combined brightly with Gonzalo Higuain who prodded within the opener before scoring a penalty once keeper Nicolas tripped Federico Bernardeschi.
Dybala then scored with a pleasant clipped shot and Douglas Costa added another from the spot once Bram Nuytinck handled within the area.
Cristiano Ronaldo withdrew from the squad once falling unwell within the day.
The 34-year-old Portuguese forward picked up a sinus infection.
Meanwhile, five-time Coppa Italia winners AC Milan defeated SPAL 3-0 to book their place within the last eight.
Polish forward Krzysztof Piatek, connected with a move faraway from the club this January, outpaced the defence to allow the home team the lead once twenty minutes.
Samuel Castillejo curled within the second simply before half-time, and Theo Hernandez hammered in the third within the 66th minute. Recent signing Zlatan Ibrahimovic remained on the bench.
Wolves player Patrick Cutrone scored eleven minutes into his loan debut for Fiorentina who defeated Atalanta 2-1.
The striker slotted home from twelve yards before Josip Ilicic equal against his recent club within the 67th minute. 3 minutes later Fiorentina were right down to ten men when German Pezzella received a second yellow card for diving.
However, La Viola secured triumph six minutes from time when pol Lirola discharged into the lowest corner.